Nebraska Urban Indian Health Coalition Alcohol, Tobacco And Other Drugs Prevention Program (Atod-Year 4) Evaluation Report: Final Report

This final report documents the major findings of an evaluation of the Alcohol, Tobacco and Other Drug Prevention Program (ATOD-Year 4) conducted by the Consortium for Organizational Research and Evaluation (CORE) of the University of Nebraska at Omaha for the Nebraska Urban Indian Health Coalition (NUIHC). The purpose of the study is to provide an analysis of several key NUIHC substance-abuse prevention initiatives. The study consists of four parts: 1) an analysis and comparison of the results obtained from NUIHC’s administration of their risk/need and outreach/discussion form, 2) an update and analysis of the results obtained from a survey of community perceptions/needs at the Omaha Metro Powwow, 3) the results obtained from a pre- and post-test of participants in NUIHC’s Strengthening Families Program (SFP) program and 4) the results obtained from post-tests of participants in NUIHC’s Protecting You/Protecting Me (PY/PM) classes

Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster

Background: Outcomes of lifespan studies in model organisms are particularly susceptible to variations in technical procedures. This is especially true of dietary restriction, which is implemented in many different ways among laboratories. Principal Findings: In this study, we have examined the effect of laboratory stock maintenance, genotype differences and microbial infection on the ability of dietary restriction (DR) to extend life in the fruit fly Drosophila melanogaster. None of these factors block the DR effect. Conclusions: These data lend support to the idea that nutrient restriction genuinely extends lifespan in flies, and that any mechanistic discoveries made with this model are of potential relevance to the determinants of lifespan in other organisms

Postcard: Visiting Rock City, Ottawa County, Kansas

This black and white photographic postcard features three different photos at the rock park in Ottawa County, Kansas. The image on the left is in a round frame and depicts a group of six people in front of the rocks with one person on top. The image on the right consists of a man and a woman in a carriage buddy with a single horse. The rocks are in the background and it is in a rectangle frame. The bottom image depicts three people sitting on top of the rocks. The image is framed in the shape of Kansas. Printed illustrations of flowers frames the pictures. Printed text is on the right side of the card.https://scholars.fhsu.edu/tj_postcards/1303/thumbnail.jp

Torts

Covers cases on contributory negligence as not a defense to wanton misconduct, on res ipsa loquitur in malpractice suits, on the standard of care having retroactive effects on building codes (Piper), on the standard of care required of persons repairing a disabled car on a highway, on conditional privilege in a libel action, and on tort actions for loss of consortium caused by the negligence of a spouse\u27s employer (Sage)

Origin of the n-type conductivity of InN: the role of positively charged dislocations

As-grown InN is known to exhibit high unintentional n-type conductivity. Hall measurements from a range of high-quality single-crystalline epitaxially grown InN films reveal a dramatic reduction in the electron density (from low 1019 to low 1017 cm–3) with increasing film thickness (from 50 to 12 000 nm). The combination of background donors from impurities and the extreme electron accumulation at InN surfaces is shown to be insufficient to reproduce the measured film thickness dependence of the free-electron density. When positively charged nitrogen vacancies (VN+) along dislocations are also included, agreement is obtained between the calculated and experimental thickness dependence of the free-electron concentration

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics

Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression. Its actions depend upon its essential ATPase, an activity fortuitously inhibited with a very high degree of selectivity by natural antibiotics: notably the actinomycete-derived benzoquinone ansamycins (e.g. geldanamycin) and certain fungal-derived resorcyclic acid lactones (e.g. radicicol). The molecular interactions made by these antibiotics when bound within the ADP/ATP-binding site of Hsp90 have served as templates for the development of several synthetic Hsp90 inhibitor drugs. Much attention now focuses on the clinical trials of these drugs. However, because microbes have evolved antibiotics to target Hsp90, it is probable that they often exploit Hsp90 inhibition when interacting with each other and with plants. Fungi known to produce Hsp90 inhibitors include mycoparasitic, as well as plant-pathogenic, endophytic and mycorrhizal species. The Hsp90 chaperone may, therefore, be a prominent target in establishing a number of mycoparasitic (interfungal), fungal pathogen–plant and symbiotic fungus–plant relationships. Furthermore the Hsp90 family proteins of the microbes that produce Hsp90 inhibitor antibiotics are able to reveal how drug resistance can arise by amino acid changes in the highly conserved ADP/ATP-binding site of Hsp90